Succinate dehydrogenase-deficient GISTs are characterized by IGF1R overexpression
نویسندگان
چکیده
منابع مشابه
Clinicopathologic study of succinate-dehydrogenase-deficient gastrointestinal stromal tumors
Gastrointestinal stromal tumors (GISTs) that are not driven by kinase mutations, as are most GISTs, often show loss of function of the succinate dehydrogenase (SDH) complex and are considered SDH-deficient GISTs. SDH-deficient GISTs share many distinct characteristics compared with conventional GISTs. However, data regarding these characteristics, particularly among Asian people, are relatively...
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Mutations in succinate dehydrogenase B (SDHB) gene are frequently observed in several tumors and associated with poor prognosis in these tumors. Therefore, drugs effective for SDHB-deficient tumors could fulfill an unmet medical need. In addition, such drugs would have an advantage in that selection of patients with SDHB-mutant cancer could increase the probability of success in clinical trials...
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Succinate dehydrogenase (SDH)-deficient renal carcinoma has been accepted as a provisional entity in the 2013 International Society of Urological Pathology Vancouver Classification. To further define its morphologic and clinical features, we studied a multi-institutional cohort of 36 SDH-deficient renal carcinomas from 27 patients, including 21 previously unreported cases. We estimate that 0.05...
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Gastrointestinal stromal tumors (GISTs) arise from the interstitial cells of Cajal (ICCs) and are the most common mesenchymal neoplasm of the gastrointestinal tract. While the majority of GISTs harbor activating mutations in either the v-kit Hardy-Zuckerman feline sarcoma viral oncogene homolog (KIT) or platelet-derived growth factor receptor alpha (PDGFRA) tyrosine kinases, approximately 10-15...
متن کاملInactivation of succinate dehydrogenase by 3-nitropropionate.
This paper examines proposals in the literature that 3-nitropropionate is a suicide inactivator of succinate dehydrogenase and that it acts by nucleophilic addition to N-5 of the covalently bound flavin component of the enzyme. With purified, soluble preparations of the enzyme, the inhibition developed slowly, and nearly complete inactivation occurred with a stoichiometric amount of 3-nitroprop...
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ژورنال
عنوان ژورنال: Modern Pathology
سال: 2012
ISSN: 0893-3952,1530-0285
DOI: 10.1038/modpathol.2012.77